MYC+ diffuse large B-cell lymphoma is not salvaged by classical R-ICE or R-DHAP followed by BEAM plus autologous stem cell transplantation.

摘要: Approximately 5-10% of diffuse large B-cell lymphomas (DLBCL) harbor a 8q24/MYC rearrangement (MYC(+)). We determined the prognostic significance MYC in patients with relapsed/refractory DLBCL prospectively treated by R-ICE or R-DHAP followed high-dose therapy and autologous stem cell transplantation. Twenty-eight (17%) 161 analyzed presented MYC(+) rearrangement, targeted as either simple hit (25%) complex hits (n=75%) including MYC/BCL2, MYC/BCL6, MYC/BCL2/BCL6. Results were statistically highly concordant matched primary relapsed biopsies (n = 45). Compared to MYC(-) patients, more elevated lactico-deshydrogenase level (P .0006) advanced age adjusted international index .0039). The 4-year PFS OS significantly lower than those rates 18% vs 42% .0322), 29% 62% .0113), respectively. Type treatment, R-ICE, had no impact on survivals, 17% 19% 26% 31%. In conclusion, is an early event DLBCL. have significant inferior prognosis patients. Their outcome was not influenced proposed salvage therapy.