Anti-resorptive therapy for osteoporosis and reduced mortality risk in elderly women and men: From the Dubbo Osteoporosis Epidemiology Study

摘要: Osteoporotic fractures and lowbonedensity (BMD) are associatedwithmortality risk antiresorptive treatmentwith reduced re-fracture andmortality risk.Mechanismsdriving these relationships unclear. The Dubbo Osteoporosis Epidemiology Study explored the between anti-resorptive osteoporosis treatment, bone loss, fracture mortality risk. Fracture data were collected from 2042 individuals all aged 60+ (1223 women 819 men) 1989 2007 with co-morbidities medication recorded 2-yearly. Of these, 325womenwere onosteoporosis treatment; 106bisphosphonates (BP), 77 hormone therapy (HT) 142 calcium±vitamin D only (CaD) as 37men (15 BP, 22 CaD). Among there 226 inwomen 68 inmen over 15 (IQR: 9–17) 14 years 7–16)with 284 deaths (101 post-fracture) in 246 (43 men. Rate of change density was available 63% (n=1291). Cox proportional hazards models used. Higher rates loss associated higher mortality; 47% greater 29% men per 3%/year loss. This largely unchanged by adjusting for frailty markers. Post-fracture, ≥1 vs 12months) treatment TPD is an increase serum levels DKK-1 that might be appearance TPD's declining pharmacological efficacy. article part a Special Issue entitled ECTS 2011. Disclosure interest: None declared. doi:10.1016/j.bone.2011.03.090