Change in Multiple Filtration Markers and Subsequent Risk of Cardiovascular Disease and Mortality.

摘要: Background and objectives Kidney disease progression, assessed by change in eGFR on the basis of creatinine, is an independent risk factor for cardiovascular death. This study aimed to evaluate whether changes multiple filtration markers, individually combined, were associated with Design, setting, participants, & measurements Creatinine, cystatin C, β2-microglobulin measured among 9716 Atherosclerosis Risk Communities Study participants 1990–1992 1996–1998. Percentage three markers (eGFR 1/β2-microglobulin) average percentage across all calculated. Cardiovascular events deaths ascertained from 1996 2011. Cox regression models adjusted established factors mortality first measurement creatinine. Results During a median follow-up 14 years, there 1922 2285 any cause. Decline >30% each marker was significantly higher compared stable kidney function (−9.9% +9.9% marker) hazard ratios (95% confidence intervals) 1.91 (1.67 2.18) 2.29 (1.99 2.63) 2.48 (2.15 2.86) 1/β2-microglobulin, similar associations disease. An decline strongly all-cause (hazard ratio, 2.82; 95% interval, 2.42 3.29). Conclusions progression using 1/β2-microglobulin