Novel perfluoroalkylated oligo(oxyethylene) methyl ethers with high hemocompatibility and excellent co-emulsifying properties for potential biomedical uses

摘要: Abstract Two series of novel perfluoroalkylated amphiphilic compounds were synthesized from monomethyl ethers mono-, di- and tri-(oxyethylene) glycols. The first CH 3 (OCH 2 ) n OCH CH(OH)CH –CF (CF CF (  = 1–3) bearing the hydroxy group at spacer between hydrophilic hydrophobic parts was prepared by reactions with 2-(perfluoroalkylmethyl)oxiranes in 76–97% yields. second possessing non-hydroxylated allyl methyl oligo(oxyethylene) glycols using radical additions perfluoroalkyl iodides subsequent selective reductions C–I bond adducts overall yields 23–69%. Some displayed very low hemolytic activity to erythrocytes excellent co-emulsifying properties on testing perfluorodecalin/Pluronic F-68 microemulsions. 1- O -(2-Hydroxy-4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluorononyl)- d -xylitol a novelized synthesis employed as standard compound testing.