Changing clinical and biological manifestations of dengue during the dengue-2 epidemic in French Polynesia in 1996/97 - description and analysis in a prospective study

摘要: In August 1996 dengue-2 virus was detected in French Polynesia for the first time since 1976. A prospective study conducted from November to April 1997. Each one of 7 physicians suspected dengue, patient enrolled and epidemiological, clinical biological data were recorded. Dengue diagnosis confirmed by isolation IgM detection. The aims this find predictive factors constituting a specific profile dengue (DF) haemorrhagic fever (DHF/DSS) assess possibility diagnosing at primary health care level using criteria basic laboratory parameters. Of 298 clinically suspect cases, 196 (66%) as dengue. association macular rash, pruritis, low platelet count leukopenia statistically but not clinically, these four signs occur many other viral infections. As prevalence manifestations varied over our study, useful cannot be defined. With six cases DHF, morbidity outbreak very despite sequential infection scheme DEN-3/DEN-2. expression could depend on strain circulating population particular place, with varying virulence time.