Interferons in the treatment of malignancies.

摘要: Interferons alpha, beta and gamma (IFN) were initially identified as soluble factors able to inhibit infection of chick chorioallantoic membranes by influenza A virus. Although the mechanism(s) action IFNs are unclear, these molecules express their biologic properties after binding specific high-affinity cell membrane receptors. To dates several clinical studies have challenged therapeutic benefits using in treatment solid tumours haematologic malignancies. The reported results shown a wide range response rate, toxicities general manageable, predictable rarely major significance. These also raised interesting possibility for improving cancer with combination conventional anticancer regimens, or combinations other Biological Response Modifiers (BRMs), such interleukin 2. Hopefully, this area research will lead an entire rethinking use our existing modalities, which perhaps could solutions old problems.