Anticardiolipin antibodies in rheumatoid patients treated with etanercept or conventional combination therapy: direct and indirect evidence for a possible association with infections.

摘要: Objective: To assess the occurrence of anticardiolipin antibodies (ACA) (as well as anti-DNA antibodies) in patients with rheumatoid arthritis treated etanercept or combination therapy. Methods: Eight 25 mg twice weekly were studied for a period 85 weeks. A control group 39 undergoing treatment (methotrexate (MTX) + cyclosporin MTX chloroquine) same time. The (ACA-IgG) and was examined, together possible infections due to bacteria capable inducing B cell activation. Results: In 5/8 receiving an increase ACA-IgG seen, while became positive 3/8 patients. nasal bronchial infection Staphylococcus aureus ( Staph ) urinary tract E coli , occurred all five cases. Antibiotic produced return normal ACA-IgG, also anti-DNA, cases except one. infectious agent eradicated subjects but found swab 10/39 subjects; ACA-IgM (followed by ACA-IgG) appeared at time 6/10, no related increased recorded other four. Conclusions: Bacterial DNA, especially that enriched CpG motifs, is powerful immunostimulant may, some cases, lead ACA positivity, once tumour necrosis factor α blocked. Eradication leads rapid decrease levels.