Parstatin Suppresses Ocular Neovascularization and Inflammation

作者: Hu Huang , Panagiotis Vasilakis , Xiufeng Zhong , Ji-Kui Shen , Katerina Geronatsiou

DOI: 10.1167/IOVS.10-5576

关键词:

摘要: Purpose. Parstatin is a 41-mer peptide formed by proteolytic cleavage on activation of the PAR1 receptor. The authors recently showed that parstatin potent inhibitor angiogenesis. purpose present study was to evaluate therapeutic effect ocular neovascularization.

参考文章(41)
Arup Das, Arup Das, Susan Majka, Paul G McGuire, Regulation of matrix metalloproteinase expression by tumor necrosis factor in a murine model of retinal neovascularization. Investigative Ophthalmology & Visual Science. ,vol. 43, pp. 260- 266 ,(2002)
L P Aiello, Vascular endothelial growth factor. 20th-century mechanisms, 21st-century therapies. Investigative Ophthalmology & Visual Science. ,vol. 38, pp. 1647- 1652 ,(1997)
Patricia Lee, Cindy C. Wang, Anthony P. Adamis, Ocular neovascularization: an epidemiologic review. Survey of Ophthalmology. ,vol. 43, pp. 245- 269 ,(1998) , 10.1016/S0039-6257(98)00035-6
LE Smith, Eva Wesolowski, Angela McLellan, Sandra K Kostyk, R D'amato, Richard Sullivan, Patricia Ann D'Amore, OXYGEN-INDUCED RETINOPATHY IN THE MOUSE Investigative Ophthalmology & Visual Science. ,vol. 35, pp. 101- 111 ,(1994)
Peter A. Campochiaro, Naoyuki Okamoto, Jeanette M. Wood, Nohoon Kwak, VEGF is major stimulator in model of choroidal neovascularization. Investigative Ophthalmology & Visual Science. ,vol. 41, pp. 3158- 3164 ,(2000)
Evangelos S. Gragoudas, Anthony P. Adamis, Emmett T. Cunningham, Matthew Feinsod, David R. Guyer, Pegaptanib for Neovascular Age-Related Macular Degeneration The New England Journal of Medicine. ,vol. 351, pp. 2805- 2816 ,(2004) , 10.1056/NEJMOA042760
A P Adamis, M Tolentino, M Kuroki, S Amano, R Rohan, Requirement for vascular endothelial growth factor in wound- and inflammation-related corneal neovascularization. Investigative Ophthalmology & Visual Science. ,vol. 39, pp. 18- 22 ,(1998)
Stanley A. Vinores, Wei-Hong Xiao, JiKui Shen, Peter A. Campochiaro, TNF-α is critical for ischemia-induced leukostasis, but not retinal neovascularization nor VEGF-induced leakage Journal of Neuroimmunology. ,vol. 182, pp. 73- 79 ,(2007) , 10.1016/J.JNEUROIM.2006.09.015
Sarah X. Zhang, Jian-xing Ma, Ocular neovascularization: Implication of endogenous angiogenic inhibitors and potential therapy. Progress in Retinal and Eye Research. ,vol. 26, pp. 1- 37 ,(2007) , 10.1016/J.PRETEYERES.2006.09.002