Gametocytocidal and sporontocidal effects of primaquine and of sulfadiazine with pyrimethamine in a chloroquine-resistant strain of Plasmodium falciparum.

摘要: Abstract Studies with 3 volunteers were conducted to determine the effects of a combination sulfadiazine and pyrimethamine primaquine upon mature gametocytes strain chloroquine-resistant Plasmodium falciparum—the Malayan (Camp.) strain. One volunteer was treated pyrimethamine; two other each received single dose 45 mg base. The pyrimethamine, although active against blood schizonts, did not exert marked sporontocidal effect In sharp contrast, primaquine, effective as schizontocide, exerted gametocytocidal this strain. The findings emphasize need for further studies drugs, particularly strains P. falciparum suggest that may come play an important role in preventing transmission such strains.