Atomic layer deposition of titanium dioxide on cellulose acetate for enhanced hemostasis.

摘要: A variety of biologically-derived hemostatic agents,including cellulose, bone wax, chitosan, collagen,and gelatin, have been utilized over the years forreducing blood loss associated with trauma [1,2].Ahemostatic agent should exhibit several properties,including (a) ability to stop hemorrhage fromarterial and/or venous sources in a short time peri-od, (b) usability minimal training, lowweight, (c) high stability, (d) low cost, (e) and bio-compatibility (e.g., absence cytotoxicity) [1–7].There are benefits use plant-derived materials such as cellulose hemostasisapplications,including an disease trans-mission from donor recipient ofantibody formation coagulation factors [8]. Cel-lulose is wood pulp-derived material that hasbeen hemostasis for 60 years;use ofoxidized oxidized regenerated cellulose,carboxymethylcellulose, acetate described [1, 9–12]. In addition, these porous,water-absorbable do not need be re-moved after because they degraded withinthe body weeks,increasing patient sat-