A Prospective Study of the Impact of Transcranial Alternating Current Stimulation on EEG Correlates of Somatosensory Perception.

摘要: The (8-12 Hz) neocortical alpha rhythm is associated with shifts in attention across sensory systems, and thought to represent a gating mechanism for the inhibitory control of cortical processing. present preliminary study sought explore whether frequency transcranial alternating current stimulation (tACS) could modulate endogenous power somatosensory system, hypothesized modulation would causally impact perception tactile stimuli at perceptual threshold. We combined electroencephalography (EEG) simultaneous brief intermittent tACS applied over primary cortex individuals' during detection task (n = 12 EEG, n 20 behavior). EEG-measured pre-stimulus was higher on non-perceived than perceived trials, analogous correlates emerged early components evoked response. Further, baseline normalized performance significantly lower sham tACS, but effect did not last into post-tACS time period. Pre- changes were linearly dependent upon state, such that tended increase when pre-tACS low, decrease it high. However, these observations comparable both groups, evidence tACS-induced modulation. Nevertheless, stimulus response potential (ERP) revealed potentially lasting circuit dynamics. ERP marked by emergence prominent peak ∼70 ms post-stimulus, which discernible post-sham, or either pre-stimulation condition. Computational neural modeling designed simulate macroscale EEG signals supported hypothesis this reflect synaptic plasticity mechanisms induced tACS. lesson learned study, commanded small sample size, while our experimental paradigm provided some an influence behavior dynamics, sufficient induce observable causal effects oscillations. discuss limitations suggest improvements may help further delineate dynamics future studies.