Acyl guanidine functional poly(2‐oxazoline)s as reactive intermediates and stimuli‐responsive materials

摘要: The many postpolymerization modification opportunities of biocompatible poly(2‐alkyl/aryl‐2‐oxazoline)s (PAOx), such as thiol–ene/thiol–yne, azide–alkyne cycloadditions, amidation, and transesterification, are one the most appealing features this polymer class for its popularity in biomedicine. Inspired by recent reports on guanidine‐catalyzed transesterification amidation reactions methyl ester substrates, we explored use guanidines a reactant functional PAOx, to obtain respective acyl guanidines. obtained polymers display reactivity toward α‐haloketones, yielding imidazole PAOx. structures protonated broad pH range, guanidine moiety is demonstrated be cleavable linker under basic conditions. © 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Chem. 2019, 57, 2616–2624