Treatment with a luteinizing hormone-releasing hormone agonist in adolescents with short stature.

作者: Jack A. Yanovski , Susan R. Rose , Giovanna Municchi , Ora H. Pescovitz , Suvimol C. Hill

DOI: 10.1056/NEJMOA013555

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摘要: Background Treatment with a luteinizing hormone–releasing hormone (LHRH) agonist increases adult height in children LHRH-dependent precocious puberty and is prescribed by some practitioners to augment short adolescents. We performed randomized clinical trial determine whether treatment an LHRH adolescents normally timed puberty. Methods Fifty (18 boys 32 girls) low predicted (mean [±SD], 3.3±1.2 SD below the population mean) received either placebo (24 subjects) or (26 subjects). The mean (±SD) duration of was 3.5±0.9 years LHRH-agonist group 2.1±1.2 (P<0.001). Adult measured when bone age exceeded 16 girls 17 rate growth less than 1.5 cm per year. Results Forty-seven (94 percent) were followed until they attained height. At time achieved,...

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