T Cell Activation in Typhoid Fever Detected by Increased Levels of Adenosine Deaminase

作者: Michele Russo , Teresa Pizzella , Salvatore Nardiello , Flavio Fiorentino , Bruno Galanti

DOI: 10.1007/978-1-4684-4553-4_49

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摘要: The demonstration of an inherited adenosine deaminase (ADA) deficiency in patients with combined immunodeficiency (Giblett et al., 1972) suggests a causal association between lymphocyte ADA levels and immune function. activity is greatly increased vitro stimulated lymphocytes (Hovi 1976) peripheral mononuclear cells from subjects developing active response (Galanti 1981). Recent data indicate that mechanisms cell-mediated immunity play the major role recovery typhoid fever (Rajagopalan 1982). aim this study to assess value assay detecting T cell activation during fever.

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