Acute effects of remote ischemic preconditioning on cutaneous microcirculation--a controlled prospective cohort study.

摘要: Therapeutic strategies aiming to reduce ischemia/reperfusion injury by conditioning tissue tolerance against ischemia appear attractive not only from a scientific perspective, but also in clinics. Although previous studies indicate that remote ischemic intermittent preconditioning (RIPC) is systemic phenomenon, few have focused on the elucidation of its mechanisms action especially clinical setting. Therefore, aim this study evaluate acute microcirculatory effects distinct cutaneous location at lower extremity which typically used as harvesting site for free flap reconstructive surgery human in-vivo Microcirculatory data 27 healthy subjects (25 males, age 24 ± 4 years, BMI 23.3) were evaluated continuously anterolateral aspect left thigh during RIPC using combined Laser-Doppler and photospectrometry (Oxygen-to-see, Lea Medizintechnik, Germany). After baseline measurement, was induced tourniquet contralateral upper arm three cycles 5 min. RIPC, oxygen saturation capillary blood flow increased up 29% 35% third reperfusion phase versus respectively (both p = 0.001). Postcapillary venous filling pressure decreased statistically significant 16% second (p 0.028). Remote affects saturation, arterial postcapillary extremity. To what extent might ameliorate soft trauma or transplantation further trials evaluate. ClinicalTrials.gov: NCT01235286