A review of drug-induced lysosomal disorders of the liver in man and laboratory animals

摘要: Lysosomotropic agents are selectively taken up into lysosomes following their administration to man and animals [de Duve et al. (1974) Biochem. Pharmacol. 23:2494–2531] The effects of lysosomotropic drugs studied in vivo vitro can be used as models lysosomal storage diseases. These include many still clinical medicine: aminoglycosides antibiotics [Tulkens (1988)]; phenothiazine derivatives; such antiparasitic chloroquine suramin; antiinflammatory like gold sodium thiomalate; cardiotonic sulmazol [Schneider (1992) Arch. Toxicol. 66:23–33]. Side-effects these caused by properties. In addition drugs, other compounds which exposed (e.g., metals, cytostatics, vitamins, hormones) also lysosomotropic. Liver cells, especially Kuppfer known accumulate agents. Here we review studies evaluate changes the liver experimental animals, relate them toxic side-effects or pharmacological action, was suggested de (1974). Common features include, overload non-digestable material; increased size number lysosomes; inhibition several enzymes; secondary increase activity some autophagy, fusion disturbances. There no significant change endocytosis, except for an Triton WR 1339 model. Microsc. Res. Tech. 36:253–275, 1997. © 1997 Wiley-Liss, Inc.