Therapeutic effect of a novel anti-parkinsonian agent zonisamide against MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)neurotoxicity in mice
作者： Hironori Yokoyama , Ryohei Yano , Hayato Kuroiwa , Tatsuya Tsukada , Hiroto Uchida
DOI: 10.1007/S11011-010-9191-0
关键词:
摘要: We investigated the therapeutic effect of zonisamide against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in mice, using Western blot analysis, immunohistochemistry and behavioral test. Our analysis immunohistochemical study showed that post-treatment with prevented significantly dopaminergic cell damage, depletion tyrosine-hydroxylase (TH) protein levels proliferation microglia striatum and/or substantia nigra 8 days after MPTP treatment. Furthermore, our attenuated motor deficits 7 These results show has model Parkinson's disease (PD) mice. also demonstrates neuroprotective damage treatment Thus present findings suggest strategies targeted to activation TH inhibition microglial may offer a great potential for restoring functional capacity surviving neurons individuals affected PD.
springer.com
sci-hub.se 参考文章(38)
Fiona Thomson, Parkinson's Disease Neuron. ,vol. 39, pp. 889- 909 ,(2003) , 10.1016/S0896-6273(03)00568-3
Barry E. Storer, Phase I Trials Wiley StatsRef: Statistics Reference Online. ,(2005) , 10.1002/9781118445112.STAT04954
Ralf Dringen, Jan M Gutterer, Johannes Hirrlinger, Glutathione metabolism in brain FEBS Journal. ,vol. 267, pp. 4912- 4916 ,(2000) , 10.1046/J.1432-1327.2000.01597.X
P. L. McGeer, S. Itagaki, B. E. Boyes, E. G. McGeer, Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains Neurology. ,vol. 38, pp. 1285- 1285 ,(1988) , 10.1212/WNL.38.8.1285
Krishnan Sriram, Karnire S. Pai, Michael R. Boyd, Vijayalakshmi Ravindranath, Evidence for generation of oxidative stress in brain by MPTP: in vitro and in vivo studies in mice Brain Research. ,vol. 749, pp. 44- 52 ,(1997) , 10.1016/S0006-8993(96)01271-1
Susan L. McElroy, Trisha Suppes, Paul E. Keck, David Black, Mark A. Frye, Lori L. Altshuler, Willem A. Nolen, Ralph W. Kupka, Gabriele S. Leverich, Jorg Walden, Heinz Grunze, Robert M. Post, Open-label adjunctive zonisamide in the treatment of bipolar disorders: A prospective trial The Journal of Clinical Psychiatry. ,vol. 66, pp. 617- 624 ,(2005) , 10.4088/JCP.V66N0512
Richard E. Heikkila, Lawrence Manzino, Felicitas S. Cabbat, Roger C. Duvoisin, Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors. Nature. ,vol. 311, pp. 467- 469 ,(1984) , 10.1038/311467A0
Anna Członkowska, Małgorzata Kohutnicka, Iwona Kurkowska-Jastrzębska, Andrzej Członkowski, Microglial Reaction in MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) Induced Parkinson's Disease Mice Model Neurodegeneration. ,vol. 5, pp. 137- 143 ,(1996) , 10.1006/NEUR.1996.0020
Aki Tanaka, Yu Watanabe, Hiroyuki Kato, Tsutomu Araki, Immunohistochemical changes related to ageing in the mouse hippocampus and subventricular zone Mechanisms of Ageing and Development. ,vol. 128, pp. 303- 310 ,(2007) , 10.1016/J.MAD.2007.01.002
Shuei Sugama, Lichuan Yang, Byung Pil Cho, Lorraine A DeGiorgio, Stefan Lorenzl, David S Albers, M.Flint Beal, Bruce T Volpe, Tong H Joh, Age-related microglial activation in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurodegeneration in C57BL/6 mice. Brain Research. ,vol. 964, pp. 288- 294 ,(2003) , 10.1016/S0006-8993(02)04085-4