Porokeratosis: A Review of its Pathophysiology, Clinical Manifestations, Diagnosis, and Treatment

摘要: Porokeratosis comprises a group of heterogeneous and uncommon acquired or congenital skin diseases unknown origin characterized by keratinization disorder resulting from abnormal clonal expansion keratinocytes. Numerous genetic mutations are thought to be involved. These conditions histologically the presence cornoid lamella. Clinical manifestations variable, with localized, disseminated, even eruptive forms. has been associated immunosuppression, ultraviolet radiation, systemic, infectious, neoplastic diseases. Many authors consider it premalignant condition because potential for malignant transformation squamous cell basal carcinoma. Therefore, long-term follow-up is key component treatment, which usually complex often unsatisfactory. We review latest advances in our understanding pathogenesis, diagnosis, treatment propose algorithm.