Effect of exposure to secondhand smoke on markers of inflammation: the ATTICA study

摘要: Abstract Purpose We sought to investigate the effect of secondhand smoke exposure on inflammatory markers related cardiovascular disease. Methods During 2001 2002, we randomly selected a stratified (age-sex) sample adults without clinical evidence Exposure (>30 minutes per day and ≥1 week) was recorded. Multivariate regression analysis used evaluate effects levels C-reactive protein, fibrinogen, homocysteine, oxidized low-density lipoprotein (LDL) cholesterol, white blood cell count. Results One hundred thirty-seven (38%) 357 men who had never smoked 211 (33%) 638 never-smoking women reported current smoke. Compared with those were not exposed smoke, more than 3 days week higher counts (by 600 cells μL; P = 0.02), as well protein 0.08 mg/dL; 0.03), homocysteine 0.4 μmol/L; 0.002), fibrinogen 5.2 0.4), LDL cholesterol 3.3 after adjusting for several potential confounders. Conclusion Our findings suggest another pathophysiological mechanism by which is associated development atherosclerosis.