Progress with the use of monoclonal antibodies for the treatment of systemic lupus erythematosus
作者： Natasha Jordan , Pamela MK Lutalo , David P D’Cruz
DOI: 10.2217/IMT.14.118
关键词:
摘要: In recent years, significant progress has been made in the use of monoclonal antibodies treatment systemic lupus erythematosus (SLE). Advances our understanding complexity SLE immunopathogenesis have led to testing several biologic agents clinical trials. Monoclonal therapies currently emerging or under development include B-cell depletion therapies, targeting survival factors, blockade T-cell co-stimulation and anticytokine therapies. Issues remain, however, regarding trial design outcome measures which need be addressed optimize translation these promising into practice.
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