Immunohistochemical expression of estrogen and progesterone receptors in human colorectal adenoma and carcinoma using specified automated cellular image analysis system: a clinicopathological study.

摘要: Objectives: To evaluate the immunohistochemical expression of estrogen receptors (ER) and progesterone (PR) in colorectal adenoma adenocarcinoma to correlate this with different clinicopathological parameters. Methods: The study was retrospectively designed. A total 86 tissue samples, including 33 paraffin blocks from patients adenomas, adenocarcinomas a control group 20 samples non-tumorous colonic tissue, were included study. Results: frequency ER PR showed gradual increase through carcinoma. frequencies control, carcinoma (10%, 15.15% 42.42% respectively, p<0.001), while for 24.24% 36.36% p<0.001). Strong staining mainly seen cases (42.42%, 36.36%, respectively) comparison (9.09%, 15.15%, (0%, 0%, respectively). three digital parameters (Area [A], Number objects [N], intensity [I]) significantly increased sequence normal mucosa-adenoma-carcinoma. There significant positive correlation between (r=0.312, p=0.034) (r=0.321, p=0.0398). Conclusion: of; mucosa-adenoma-carcinoma, observed specimen indicating that may play role carcinogenesis.