99mTc-MIBI scintigraphy for early detection of locally recurrent non-small cell lung cancer treated with definitive radiation therapy.

摘要: After radiation therapy of lung cancer, a dense fibrotic shadow develops in the irradiated lung. Owing to this fibrosis, early detection local recurrence after treatment is sometimes difficult even when using com- puted tomography (CT) and magnetic resonance imag- ing. We investigated diagnostic accuracy techne- tium-99m hexakis 2-methoxyisobutylisonitrile ( 99m Tc- MIBI) scintigraphy for recurrent cancer following definitive therapy. Eighteen patients with primary non-small cell treated 1 year previously were studied Tc-MIBI scintigraphy. They showed no evidence on serial chest radiographs. All sin- gle-photon emission (SPET) images ac- quired 2 h intravenous administration radio- pharmaceutical visually interpreted knowl- edge pretreatment radiograph, CT details (radiation portals admin- istered doses). A region interest (ROI) analysis was also performed. In addition ROI ratio tumour uptake accumulation contralateral normal (tu- mour/lung ratio), another semiquantitative analysis, fi- brosis (tumour/fibrosis performed differen- tiate between fibrosis uptake. The scintigraphic diagnoses corre- lated clinical outcome. sensitivity, specificity negative predictive value 99mTc-MIBI scintigra- phy all 88.9% (8/9). tumour/lung ratios (mean±SEM) nine other eight without failure 2.00±0.11 1.40±0.09, re- spectively (P<0.01). tumour/fibrosis pa- tients those 1.47±0.08 0.93±0.05, respectively These results sug- gest that might be especially small foci areas are hardly noticeable