Multi-objective Evolutionary Probe Design Based on Thermodynamic Criteria for HPV Detection
作者： In-Hee Lee , Sun Kim , Byoung-Tak Zhang
DOI: 10.1007/978-3-540-28633-2_78
关键词:
摘要: DNA microarrays are widely used techniques in molecular biology and computing area. It consists of the sequences called probes, which complementaries to genes interest, on solid surfaces. And its reliability seriously depends quality probe sequences. Therefore, one must carefully choose sets target In this paper, design for is formulated as multi-objective optimization problem. We propose a evolutionary approach, known be suitable kind Since algorithm can find multiple solutions at time, we thermodynamic criteria most one. For experiments, set generated by proposed method compared commercial microarrays, detects Human Papillomavirus (HPV). The comparison result supports that our approach useful optimize
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