The roles and perspectives of microRNAs as biomarkers for intervertebral disc degeneration.
作者： Xiaoya Zhou , Lili Chen , Sibylle Grad , Mauro Alini , Haobo Pan
DOI: 10.1002/TERM.2261
关键词:
摘要: MicroRNAs (miRNAs) are highly conserved molecules that regulate protein levels post-transcriptionally. Aberrant miRNA expression presents in various musculoskeletal disorders, such as osteoporosis, osteoarthritis and rheumatoid arthritis. The of miRNAs characterized by endogenous properties tissue specificity. This raises the possibility could serve useful clinical biomarkers diagnosis certain diseases. Intervertebral disc degeneration (IDD) is one major causes back pain, a process cascade molecular, cellular, biochemical structural changes. presence dysregulated patients with diseases indicates may play vital role pathogenesis IDD. Here, we provide an introduction roles IDD, prospective application for Copyright © 2017 John Wiley & Sons, Ltd.
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