B cell homeostasis and follicle confines are governed by fibroblastic reticular cells

摘要: Fibroblastic reticular cells (FRCs) are known to inhabit T cell-rich areas of lymphoid organs, where they function facilitate interactions between and dendritic cells. However, in vivo manipulation FRCs has been limited by a dearth genetic tools that target this lineage. Here, using mouse model conditionally ablate FRCs, we demonstrated their indispensable role antiviral cell responses. Unexpectedly, loss also attenuated humoral immunity due impaired B viability follicular organization. Follicle-resident established favorable niche for lymphocytes via production the cytokine BAFF. Thus, our study indicates adaptive requires an intact FRC network identifies subset control homeostasis follicle identity.