Prognostic value of paranasopharyngeal extension of nasopharyngeal carcinoma: A significant factor in local control and distant metastasis

摘要: BACKGROUND This study was conducted to evaluate the prognostic value of paranasopharyngeal extension in local control and distant metastasis patients with nasopharyngeal carcinoma. METHODS Three hundred sixty-four newly diagnosed carcinoma without were reviewed. Patients staged according Ho's staging system. Using a semiquantitative method, tumor into space graded as: 0: no extension; 1:-extension retrostyloid space; 2:-extension prestyloid 3:-extension anterior part masticator space. All received radiotherapy as primary treatment. Median follow-up time 45 months (range, 4.7 76.5 months). Relapse free, relapse free survival estimated using Kaplan-Meier method. Cox regression also performed adjust for factors. RESULTS The incidence high (72.5%). Of these patients, 65.5% had Grade 2 or 3 extension. The 5-year rates 0, 1, 2, 76%, 70%, 46%, 43%, respectively. main difference between 0/1 2/3 extension, latter having lower rate (86% vs. 72% 2/3; P < 0.0001) (87% 68% = 0.0002). Multivariate analysis showed that an independent factor predicting overall relapse, metastasis. Advanced T classification (T3) another whereas advanced N (N3) metastasis. CONCLUSIONS Extensive (Grade 2/3) associated poorer treatment outcome, both T2 disease should be further subclassified T2a T2b, which include disease, Cancer 1996; 78:202-10.