Increased stroke risk predicted by compromised cerebral blood flow reactivity.

摘要: The authors sought to determine risk for stroke in individuals with symptomatic carotid stenosis or occlusion based upon an assessment of cerebral blood flow (CBF) reserves. Vascular reserve was assessed by two consecutive xenon/computerized tomography (Xe/CT) CBF studies intravenous acetazolamide introduced 20 minutes prior the second study. Patients were assigned one vasoreactivity groups. Group 2 included who experienced a reduction more than 5% at least vascular territory and had baseline 45 cc/100 gm/min less. 1 all other individuals. Any volume loss on CT 50% eliminated from analysis. Sixty-eight followed 6-month intervals mean 24 months. In strokes observed contralateral side lowest reserve, incidence 4.4%; eight ipsilateral 36%. latter group 12.6 times greater chance (p = 0.0007). History stroke, history transient ischemic attacks, CBF, degree not associated increased rate. this study, significantly compromised reserves accompanied relatively low initial identified subsequently demonstrated rate stroke.