Cutting Edge: KIR2DL4 Transduces Signals into Human NK Cells through Association with the Fc Receptor γ Protein

摘要: KIR2DL4 (2DL4, CD158d), a member of the human killer cell Ig-like receptor (KIR) family, triggers potent IFN-gamma responses but weak cytotoxicity in resting NK cells. 2DL4 mRNA has been detected most clones from humans examined, surface protein expression is detectable only on CD56(high) cells certain donors. The possesses transmembrane arginine residue, suggesting association with signaling accessory that remained elusive. We provide biochemical and functional evidence FcepsilonRI-gamma (gamma) associates to promote signal transducing function. Weak cytolytic triggered through may result low stoichiometric gamma. Selective gamma distinguishes all other activating forms KIR which alternatively associate DNAX-activating (DAP)12.