Biosynthesis of hypusine in eIF-4D precursors.
作者： M. H. Park , E. C. Wolff , A. Abbruzzese , J. E. Folk
DOI: 10.1007/978-1-4684-5637-0_38
关键词:
摘要: An unusual basic amino acid hypusine was discovered in 1971 extracts of bovine brain by Shiba and coworkers, who determined its chemical structure as Ne -(4-amino-2-hydroxybutyl)lysine(1). Its distribution various animal tissues the free (2) a component protein (3) subsequently reported. Initial attempts to isolate any specific that contained were unsucessful, however (3). Ten years after discovery hypusine, we observed radiolabeling single cellular (Mr 183000, pI 5.3) upon incubation human peripheral lymphocytes with [1, 8- 3H] spermidine or [2, 3- putrescine presence mitogen, phytohemagglutinin identified polyamine-derived radioactive this (4).
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sci-hub.st 参考文章(26)
R F Duncan, J W Hershey, Changes in eIF-4D hypusine modification or abundance are not correlated with translational repression in HeLa cells. Journal of Biological Chemistry. ,vol. 261, pp. 12903- 12906 ,(1986) , 10.1016/S0021-9258(18)67178-9
M H Park, E C Wolff, Cell-free synthesis of deoxyhypusine. Separation of protein substrate and enzyme and identification of 1,3-diaminopropane as a product of spermidine cleavage. Journal of Biological Chemistry. ,vol. 263, pp. 15264- 15269 ,(1988) , 10.1016/S0021-9258(19)37582-9
M H Park, The identification of an eukaryotic initiation factor 4D precursor in spermidine-depleted Chinese hamster ovary cells. Journal of Biological Chemistry. ,vol. 263, pp. 7447- 7449 ,(1988) , 10.1016/S0021-9258(18)68516-3
R J Murphey, E W Gerner, Hypusine formation in protein by a two-step process in cell lysates. Journal of Biological Chemistry. ,vol. 262, pp. 15033- 15036 ,(1987) , 10.1016/S0021-9258(18)48133-1
Regulation of biosynthesis of hypusine in Chinese hamster ovary cells. Evidence for eIF-4D precursor polypeptides. Journal of Biological Chemistry. ,vol. 262, pp. 12730- 12734 ,(1987) , 10.1016/S0021-9258(18)45267-2
M H Park, D J Liberato, A L Yergey, J E Folk, The biosynthesis of hypusine (N epsilon-(4-amino-2-hydroxybutyl)lysine). Alignment of the butylamine segment and source of the secondary amino nitrogen. Journal of Biological Chemistry. ,vol. 259, pp. 12123- 12127 ,(1984) , 10.1016/S0021-9258(20)71329-3
M H Park, T Y Liu, S H Neece, W J Swiggard, Eukaryotic initiation factor 4D. Purification from human red blood cells and the sequence of amino acids around its single hypusine residue. Journal of Biological Chemistry. ,vol. 261, pp. 14515- 14519 ,(1986) , 10.1016/S0021-9258(18)66899-1
M H Park, J E Folk, Biosynthetic labeling of hypusine in mammalian cells. Carbon-hydrogen bond fissions revealed by dual labeling. Journal of Biological Chemistry. ,vol. 261, pp. 14108- 14111 ,(1986) , 10.1016/S0021-9258(18)66988-1
M H Park, H L Cooper, J E Folk, The biosynthesis of protein-bound hypusine (N epsilon -(4-amino-2-hydroxybutyl)lysine). Lysine as the amino acid precursor and the intermediate role of deoxyhypusine (N epsilon -(4-aminobutyl)lysine). Journal of Biological Chemistry. ,vol. 257, pp. 7217- 7222 ,(1982) , 10.1016/S0021-9258(18)34559-9
Kari I. Kivirikko, Raili Myllylä, Posttranslational enzymes in the biosynthesis of collagen: intracellular enzymes. Methods in Enzymology. ,vol. 82, pp. 245- 304 ,(1982) , 10.1016/0076-6879(82)82067-3