Guinea pigs as models to study the hypocholesterolemic effects of drugs.
作者： Kristy L. West , Maria Fernandez
DOI: 10.1111/J.1527-3466.2004.TB00131.X
关键词:
摘要: Guinea pigs are useful models to investigate the mechanisms of hypocholesterolemic effects drugs. Like humans, guinea one few species that carry majority cholesterol in LDL. This animal model has also been shown develop atherosclerosis when challenged with hypercholesterolemic diets. In addition, plasma lipid profiles males, females and ovariectomized pigs, a for menopause, follow similar patterns those observed humans. this report, drugs aimed at lowering triglycerides hyperlipidemic individuals reviewed. Studies analyzing hypolipidemic effect HMG-CoA reductase inhibitors, acyl CoA acyltransferase fibrates, bile acid resins, apical sodium transporter others show humans have comparable responses drug therapy. results from limited clinical reports addressing specific on LDL catabolism or VLDL synthesis agreement observations pigs. From review these studies, it is apparent pig further explore action including receptors regulatory enzymes involved metabolism early development.
sci-hub.se 参考文章(88)
Jeffrey M. Peters, Nathalie Hennuyer, Bart Staels, Jean-Charles Fruchart, Catherine Fievet, Frank J. Gonzalez, Johan Auwerx, Alterations in Lipoprotein Metabolism in Peroxisome Proliferator-activated Receptor α-deficient Mice Journal of Biological Chemistry. ,vol. 272, pp. 27307- 27312 ,(1997) , 10.1074/JBC.272.43.27307
Rebecca G Bakker-Arkema, Michael H Davidson, Robert J Goldstein, Jean Davignon, Jonathan L Isaacsohn, Stuart R Weiss, Leonard M Keilson, W Virgil Brown, Valery T Miller, Linda J Shurzinske, Donald M Black, Efficacy and Safety of a New HMG-CoA Reductase Inhibitor, Atorvastatin, in Patients With Hypertriglyceridemia JAMA: The Journal of the American Medical Association. ,vol. 275, pp. 128- 133 ,(1996) , 10.1001/JAMA.1996.03530260042029
S. D. Turley, C. E. West, Effect of cholesterol and cholestyramine feeding and of fasting on sterol synthesis in the liver, ileum, and lung of the guinea pig Lipids. ,vol. 11, pp. 571- 577 ,(1976) , 10.1007/BF02532904
J L Witztum, S G Young, R L Elam, T E Carew, M Fisher, Cholestyramine-induced changes in low density lipoprotein composition and metabolism. I. Studies in the guinea pig. Journal of Lipid Research. ,vol. 26, pp. 92- 103 ,(1985) , 10.1016/S0022-2275(20)34408-4
B Staels, N Vu-Dac, V A Kosykh, R Saladin, J C Fruchart, J Dallongeville, J Auwerx, Fibrates downregulate apolipoprotein C-III expression independent of induction of peroxisomal acyl coenzyme A oxidase. A potential mechanism for the hypolipidemic action of fibrates. Journal of Clinical Investigation. ,vol. 95, pp. 705- 712 ,(1995) , 10.1172/JCI117717
A Swann, M H Wiley, M D Siperstein, Tissue distribution of cholesterol feedback control in the guinea pig. Journal of Lipid Research. ,vol. 16, pp. 360- 366 ,(1975) , 10.1016/S0022-2275(20)34527-2
Steven M. Haffner, Secondary prevention of coronary heart disease: the role of fibric acids. Circulation. ,vol. 102, pp. 2- 4 ,(2000) , 10.1161/01.CIR.102.1.2
Akira Matsunaga, Jun Sasaki, Yoichi Takada, Kazuko Hidaka, Kikuo Arakawa, Effect of simvastatin on receptor mediated metabolism of low density lipoprotein in guinea pigs. Atherosclerosis. ,vol. 90, pp. 31- 37 ,(1991) , 10.1016/0021-9150(91)90241-T
Therese M. Heinonen, Evan Stein, Stuart R. Weiss, James M. McKenney, Michael Davidson, Linda Shurzinske, Donald M. Black, The lipid-lowering effects of atorvastatin, a new HMG-CoA reductase inhibitor: results of a randomized, double-masked study. Clinical Therapeutics. ,vol. 18, pp. 853- 863 ,(1996) , 10.1016/S0149-2918(96)80045-2
D K Spady, S D Turley, J M Dietschy, Role of liver in the maintenance of cholesterol and low density lipoprotein homeostasis in different animal species, including humans. Journal of Lipid Research. ,vol. 34, pp. 1637- 1659 ,(1993) , 10.1016/S0022-2275(20)35728-X