Components of Biological Variation of Biochemical Markers of Bone Turnover in Paget's Bone Disease

摘要: The aims of this study were to evaluate the components biological variation new markers bone turnover in patients with Paget's disease and compare results data obtained healthy subjects. Fifteen a stable period 12 premenopausal women included for 1 year follow-up study. Within- between-subject variation, indices individuality, critical differences evaluated following biochemical markers: serum, total (tAP), (bAP) alkaline phosphatases, procollagen type I N-terminal propeptide (PINP) beta-carboxyterminal telopeptide collagen (sCTx); urine, hydroxyproline (Hyp), amino (NTx) (CTx) telopeptides I. Serum showed lower variability than urinary markers. Within-subject was higher pagetic subjects all serum In both groups, bAP presented lowest within-subject variation. patients, individuality <0.6, indicating their usefulness patient monitoring. Critical Among PINP values close 30%, whereas CTx highest (near 70%). Conversely, subjects, tAP marker differences, being two-fold patients. This confirms sensitivity detect significant changes indicates that on variations from populations cannot always be extrapolated pathological conditions. addition, seem best reflect change activity disease.