New Functions for Old Genes in the Mouse Placenta

作者: Umashankar Singh

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摘要: Carboxypeptidase E (CPE) has important functions in processing of endocrine pro-peptides, such as pro-insulin, pro-opiomelanocortin, or pro-gonadotropin-releasing hormone, evidenced by the hyperpro-insulinemia, obesity, and sterility Cpe mutant mice. Down-regulation enlarged placentas interspecific hybrid (interspecies placental dysplasia (IHPD)) cloned mice suggested that reduced CPE enzyme receptor activity could underlie abnormal phenotypes. In this study, we have explored role murine placentation determining its expression at various stages gestation, phenotypic analysis placentas. Our results show D (Cpd), another carboxypeptidase with a very similar function, are strictly co-localized mouse placenta from late mid-gestation to term. We also absence causes sporadic but striking phenotype characterized an increase giant glycogen cell numbers hypertrophy. Microarray-based transcriptional pro. ling identified only small number genes altered expression, including Dtprp, which belongs prolactin gene family. Concordant deregulation Cpd interspecies hybrids before onset IHPD recapitulation some phenotypes hyperplastic suggests these two causally involved may function speciation genus Mus.

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