Gait Speed, Body Composition, and Dementia. The EPIDOS-Toulouse Cohort

摘要: BACKGROUND Slow gait speed (GS) predicts dementia, but this association might be mediated by body composition parameters like total fat mass (TFM) or lean (TLM). The aim of the study was to evaluate whether GS, TLM, and TFM were associated factors with an increased risk for subsequent dementia in community-dwelling older women. METHODS A case-control nested EPIDemiologie de l'OSteoporose cohort. GS (at usual pace more than 6 m), (assessed dual energy x-ray absorptiometry) measured at baseline. Cognitive performance evaluated baseline 7 years follow-up. presence assured two blinded memory experts based on best practice validated criteria. Multivariate logistic regression models assessed risk. RESULTS Of initial 1,462 women, 75 old older, 647 (43.4%) cognitively intact had a full cognitive assessment (145 them developed dementia). Controlled covariates (demographics, physical activity, self-reported disabilities, comorbidities), independent factor as continuous variable (odds ratio [OR] 2.28, 95% CI: 1.32-3.94) categorized (OR 2.38, 1.28-4.43 highest vs lowest quartile). Neither interaction nor statistically significant found TLM TFM. CONCLUSIONS not