The increased expression of glucose transporters in human full-term placentas from assisted reproductive technology without changes of mTOR signaling.

摘要: Abstract Objective In the mouse model, manipulations of assisted reproductive technology (ART) can lead to enlarged placentas and influence expression glucose transporters (GLUTs) in during mid-to late-gestation. Expression imprinted genes which plays a vital role placental growth function, is also vulnerable be affected by ART. However, it uncertain whether those abnormal changes presented ART occur human placentas. Methods We compared GLUT family (SLC2A1- SLC2A13), mTOR activity, four (H19, IGF2, CDKN1C PHLDA2), KCNQ1OT1 methylation conceived naturally or Results Our data showed that weight birthweight were similar between NC (n = 20) group (n = 20). found up-regulated mRNA GLUTs elevated GLUT1 protein level occurred with unchanged activity. And we PHLDA2 significantly increased from natural pregnancies. Additionally, revealed had negatively controls expression. Conclusion This study reveals occurs normal The down-regulated gene may account for up-regulation GLUTs. Those adaptive explain why most offspring have birth at born.