Clinical Significance and Systematic Expression Analysis of the Thyroid Receptor Interacting Protein 13 (TRIP13) as Human Gliomas Biomarker.
作者： Wen-Chiuan Tsai , Dueng-Yuan Hueng , Yao-Feng Li , Hong-Han Lin , Ssu-Han Chen
关键词:
摘要: The prognosis of malignant gliomas such as glioblastoma multiforme (GBM) has remained poor due to limited therapeutic strategies. Thus, it is pivotal determine prognostic factors for gliomas. Thyroid Receptor Interacting Protein 13 (TRIP13) was found be overexpressed in several solid tumors, but its role and clinical significance still unclear. Here, we conducted a comprehensive expression analysis TRIP13 the values. Gene profiles Cancer Genome Atlas (TCGA), Chinese Glioma (CGGA) GSE16011 dataset showed increased advanced stage worse IDH-wild type lower-grade glioma. We performed RT-PCR Western blot validate mRNA protein levels GBM cell lines. co-expressed genes via database screening were regulated by essential cancer-related upstream regulators (such TP53 FOXM1). Then, TCGA revealed that more promoter hypomethylation observed than low-grade also inferred upregulated could dysfunction miR-29 patient cohorts. Moreover, TRIP13-expressing tumors not only had higher aneuploidy tended reduce ratio CD8+/Treg, which led survival outcome. Overall, these findings demonstrate with multiple functions gliomas, they may crucial potential.
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