The association between blood donor sex and age and transfusion recipient mortality: an exploratory analysis.

摘要: Background There is recent support for long-term adverse effects of donor-recipient sex-mismatched red blood cell (RBC) transfusion, but short-term impact unknown. A retrospective exploratory analysis was performed using data from a research database. Methods Adults admitted to hospitals in one Canadian center who received RBCs (2008-2014 [3 sites]; 2012-2014 [1 site]) were eligible. Patient extracted database and donor the supplier. Cox regression models used, with control risk confounding variables as covariates or stratification. Exposure defined by mutually exclusive categories. The outcome in-hospital mortality. Results total 25,219 adults 97,886 RBCs. Diagnoses included cardiovascular (28.8%), neoplastic (15.6%), traumatic (15.4%), gastrointestinal (10.5%); 56.3% transfused male donors, median age 45 years (interquartile range, 30-54). Female patients exposed experienced higher death (hazard ratio [HR], 1.31; 95% confidence interval [CI], 1.02-1.69; p = 0.038) compared female RBC exposure. donors aged younger associated (HR, 1.21; CI, 1.02-1.44; 0.026) exposure older than years. Donor-recipient (vs. exclusively sex-matched) >45) increased mortality: 1.23; (95% 1.04-1.45; 0.017); 1.02-1.43; 0.031). Conclusion sex-matched transfusions may benefit patients.