Non-Hodgkin Lymphoma Risk and Variants in Genes Controlling Lymphocyte Development

摘要: Non-Hodgkin lymphomas (NHL) are a heterogeneous group of solid tumours lymphoid cell origin. Three important aspects lymphocyte development include immunity and inflammation, DNA repair, programmed death. We have used previously established case-control study NHL to ask whether genetic variation in genes involved these three processes influences risk this cancer. 118 categories were tagged with single nucleotide polymorphisms (SNPs), which tested for association its subtypes. The main analysis logistic regression (additive model) estimate odds ratios European-ancestry cases controls. 599 SNPs 1116 samples (569 547 controls) passed quality control measures included analyses. Following multiple-testing correction, one SNP MSH3, mismatch repair gene, showed an diffuse large B-cell lymphoma (OR: 1.91; 95% CI: 1.41–2.59; uncorrected p=0.00003; corrected p=0.010). This was not replicated independent sample set 251 737 controls, indicating result likely false positive. It is that moderate size, inter-subtype other heterogeneity, small true effect sizes account the lack replicable findings.