131I-labeled and DOX-loaded multifunctional nanoliposomes for radiotherapy and chemotherapy in brain gliomas

摘要: The codelivery of different therapeutics is a promising option because its synergetic effects drugs. In this study, new combination therapy that used the doxorubicin-loaded and 131I-labeled nanoliposomes (131I-DOX-NL) was proposed to delay tumor growth gliomas, which are characterized by significant mortality morbidity. 131I-DOX-NL constructed based on bovine serum albumin (BSA)-tailor made hydrophobic maleimide-functionalized poly(e-caprolactone) (PCL) (Fig. 1) evaluated cellular viability in vitro U87 xenograft models vivo. Compared with using 131I-NL or DOX-NL alone, our experimental results show exhibits similar high uptake but enhanced efficacy cure gliomas 131I DOX. mouse models, resulted higher survival rates mice smaller sizes than monotherapy did alone. conclusion, multifunctional nanoliposome good candidate for 131I-mediated radiotherapy DOX-mediated chemotherapy due ability inhibit cell proliferation growth. can be as effective malignant deserves further investigation.