Adiponectin and Adiponectin Receptors in Obesity-Linked Insulin Resistance

摘要: Adiponectin is an abundantly expressed adipokine in adipose tissue and has direct insulin sensitizing activity. We have proposed the following adiponectin hypothesis. Interactions of genetic factors such as single nucleotide polymorphisms (SNPs) gene environmental causing obesity result hypoadiponectinaemia, which appears to play important causal role obesity-linked resistance, type 2 diabetes metabolic syndrome. cloned receptors, AdipoR1 AdipoR2, mediate antidiabetic actions adiponectin. AdipoR2 are down-regulated resistance. Up-regulation or receptors may represent potential versatile therapeutic targets combat diseases characterized by