摘要: 1 Introduction 2 Classification 3 Structure and Life Cycle 4 Biochemistry, Molecular Biology, Genetics 5 Clinical Aspects 6 Immunology 7 Pathology 8 Diagnosis 9 Epidemiology 10 Chemotherapy Treatment 11 Vaccination 12 Integrated Control Keywords: old world leishmaniasis; leishmaniases-group of human diseases afflicting people; five species Leishmania-L. major, L. tropica, aethiopica, donovani, infantum; zymodeme-group strains sharing given pattern enzyme electrophoretic mobilities; parasites in two morphological forms-‘amastigotes’ ‘promastigotes’; amastigotes-ovoid, non-motile, intracellular stages; promastigotes-elongated, motile, extracellular stages; lysosomes cytoplasm together with organelles; promastigote surface protease, lipophosphoglycan glycosylphosphatidylinositols
sci-hub.st 参考文章(149)
Pierre Marty, Yves Le Fichoux, Francine Pratlong, Martine Gari-Toussaint, Human visceral leishmaniasis in Alpes-Maritimes, France: epidemiological characteristics for the period 1985–1992 Transactions of The Royal Society of Tropical Medicine and Hygiene. ,vol. 88, pp. 33- 34 ,(1994) , 10.1016/0035-9203(94)90485-5
Uwe Ritter, Heinrich Korner, Divergent expression of inflammatory dermal chemokines in cutaneous leishmaniasis Parasite Immunology. ,vol. 24, pp. 295- 301 ,(2002) , 10.1046/J.1365-3024.2002.00467.X
MICHAEL Kemp, JØRGEN A. L. Kurtzhals, ARSALAN Kharazmi, THOR G. Theander, Dichotomy in the human CD4+ T‐cell response to Leishmania parasites Apmis. ,vol. 102, pp. 81- 88 ,(1994) , 10.1111/J.1699-0463.1994.TB04850.X
T. Ilg, Proteophosphoglycans of Leishmania Parasitology Today. ,vol. 16, pp. 489- 497 ,(2000) , 10.1016/S0169-4758(00)01791-9
Chitinase secreted by Leishmania functions in the sandfly vector. Proceedings of The Royal Society B: Biological Sciences. ,vol. 245, pp. 121- 126 ,(1991) , 10.1098/RSPB.1991.0097
P.A. Bates, The Developmental Biology of Leishmania Promastigotes Experimental Parasitology. ,vol. 79, pp. 215- 218 ,(1994) , 10.1006/EXPR.1994.1084
Shaden Kamhawi, The biological and immunomodulatory properties of sand fly saliva and its role in the establishment of Leishmania infections. Microbes and Infection. ,vol. 2, pp. 1765- 1773 ,(2000) , 10.1016/S1286-4579(00)01331-9
TK Jha, Shyam Sundar, CP Thakur, Peter Bachmann, Juntra Karbwang, Christina Fischer, Andreas Voss, Jonathan Berman, None, Miltefosine, an oral agent, for the treatment of Indian visceral leishmaniasis. The New England Journal of Medicine. ,vol. 341, pp. 1795- 1800 ,(1999) , 10.1056/NEJM199912093412403
M. L. CHANCE, P. A. BATES, M. E. ROGERS, The role of promastigote secretory gel in the origin and transmission of the infective stage of Leishmania mexicana by the sandfly Lutzomyia longipalpis Parasitology. ,vol. 124, pp. 495- 507 ,(2002) , 10.1017/S0031182002001439
Y. Schlein, R. L. Jacobson, G. Messer, Leishmania infections damage the feeding mechanism of the sandfly vector and implement parasite transmission by bite. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 89, pp. 9944- 9948 ,(1992) , 10.1073/PNAS.89.20.9944