Chemokine mutants in the treatment of multiple sclerosis
作者： Marie Kosco-Vilbois , Timothy N.C. Wells , Amanda Proudfoot
DOI:
关键词:
摘要: Mutants of CC chemokines, which contain at least two mutations in the cationic site 40's loop and which, relative to wild-type molecule, have a reduced GAG-binding activity. In particular it has been found that such mutated chemokines are effective treatment multiple sclerosis and/or other demyelinating diseases. A triple mutant RANTES is compound showing best results.
lens.org 参考文章(12)
G. J. Graham, P. C. Wilkinson, R. J. Nibbs, S. Lowe, S. O. Kolset, A. Parker, M. G. Freshney, M. L. Tsang, I. B. Pragnell, Uncoupling of stem cell inhibition from monocyte chemoattraction in MIP-1alpha by mutagenesis of the proteoglycan binding site. The EMBO Journal. ,vol. 15, pp. 6506- 6515 ,(1996) , 10.1002/J.1460-2075.1996.TB01041.X
Paolo Lusso, Simona Polo, RANTES mutants and therapeutic applications thereof ,(1998)
Paul Proost, Jo Van Damme, Sofie Struyf, Amino-terminally truncated rantes as chemokine antagonists ,(1998)
Gabriele S. V. Kuschert, Florence Coulin, Christine A. Power, Amanda E. I. Proudfoot, Rod E. Hubbard, Arlene J. Hoogewerf, Timothy N. C. Wells, Glycosaminoglycans interact selectively with chemokines and modulate receptor binding and cellular responses. Biochemistry. ,vol. 38, pp. 12959- 12968 ,(1999) , 10.1021/BI990711D
Victor Appay, Anthony Brown, Scott Cribbes, Eliot Randle, Lloyd G. Czaplewski, Aggregation of RANTES Is Responsible for Its Inflammatory Properties CHARACTERIZATION OF NONAGGREGATING, NONINFLAMMATORY RANTES MUTANTS Journal of Biological Chemistry. ,vol. 274, pp. 27505- 27512 ,(1999) , 10.1074/JBC.274.39.27505
Amanda E. I. Proudfoot, Sarah Fritchley, Frédéric Borlat, Jeffrey P. Shaw, Francis Vilbois, Catherine Zwahlen, Alexandra Trkola, David Marchant, Paul R. Clapham, Timothy N. C. Wells, The BBXB Motif of RANTES Is the Principal Site for Heparin Binding and Controls Receptor Selectivity Journal of Biological Chemistry. ,vol. 276, pp. 10620- 10626 ,(2001) , 10.1074/JBC.M010867200
Witte Koopmann, Michael S. Krangel, Identification of a Glycosaminoglycan-binding Site in Chemokine Macrophage Inflammatory Protein-1α Journal of Biological Chemistry. ,vol. 272, pp. 10103- 10109 ,(1997) , 10.1074/JBC.272.15.10103
Arlene J. Hoogewerf, Gabriele S. V. Kuschert, Amanda E. I. Proudfoot, Frederic Borlat, Ian Clark-Lewis, Christine A. Power, Timothy N. C. Wells, Glycosaminoglycans Mediate Cell Surface Oligomerization of Chemokines Biochemistry. ,vol. 36, pp. 13570- 13578 ,(1997) , 10.1021/BI971125S
Jennifer S. Laurence, Cédric Blanpain, Anne De Leener, Marc Parmentier, Patricia J. LiWang, Importance of Basic Residues and Quaternary Structure in the Function of MIP-1β: CCR5 Binding and Cell Surface Sugar Interactions† Biochemistry. ,vol. 40, pp. 4990- 4999 ,(2001) , 10.1021/BI002593W
Barrett Rollins, Yujun Zhang, Chemokine N-terminal deletion mutations ,(1996)