Methods of identifying, isolating and using odorant and aroma receptors

作者: Khalid Jerod Parris , Patrick Pfister , Matthew E. Rogers

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摘要: Provided here are new methods to identify specific families of mammalian odorant receptors for odorants or aroma, particularly indole and skatole malodors their use in assays that may be used discover compounds modulate (blocking, enhancing, masking mimicking compounds) activity. Orphan mouse identified from olfactory sensory neurons respond target compounds. The resulting as well human counterparts can screened against test confirm identity aroma receptors, malodor subsequently example modulators inhibit the perception humans.

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