Serum cholesterol reduction with tamoxifen.

摘要: The serum cholesterol levels of 123 consecutively and newly diagnosed women with Stage I II breast cancer taking tamoxifen were compared a control group 81 who not hormonal treatment or supplement. Other factors that evaluated age, menopausal status, tumor size, weight, height, Quetelet index, smoking alcohol intake history. mean change in patients on (34.2 ± 3.6 mg/dl) was significantly greater than controls (1.0 4.1 (P<0.001). Serum fell by more 10 mg/dl 72.9% vs. 35.1% 40 39.9% 12.6% controls. Multivariate analysis revealed administration (P<0.0001), initial level (P = 0.001), age 0.04) significant producing decrease cholesterol. as adjuvant therapy to resulted fall This effect the may prove be an additional benefit form reduced cardiovascular risk these women.