Preferable effect of pravastatin compared to atorvastatin on beta cell function in Japanese early-state type 2 diabetes with hypercholesterolemia.

摘要: While a large numbers of clinical trials using various kinds statins has been reported, possible preventive effect on new onset type 2 diabetes mellitus was shown only by the subanalysis The West Scotland Coronary Prevention Study (WOSCOPS) pravastatin. aim this study to investigate whether pravastatin preferable glucose tolerance among statins. An open-label prospective cross-over trial performed compare (10 mg/day) or atorvastatin in Japanese early-state with hypercholesterolemia. analyzed subjects were treated mg/day, n = 12) for 12 weeks. After 4-week-washout period, drugs switched and treatment continued another Oral test (OGTT) evaluate several parameters including appropriateness beta cell function individual insulin sensitivity (disposition index: product validated secretion parameter sensitivity) at end each therapy. HbA1c h-glucose levels during OGTT significantly lower than treatment. Disposition index after higher In conclusion, our suggests that favorable pancreatic compared atorvastatin.