Natural history of tinnitus in adults: a cross-sectional and longitudinal analysis

摘要: Objective To assess incidence and changes in tinnitus bothersome as well associated risk factors a large sample of UK adults. Design Prospective cohort study. Setting UK. Participants For cross-sectional analysis, group 168 348 participants aged between 40 69 years with hearing data from the Biobank resource. Longitudinal analysis included subset 4746 people who attended 4-year retest assessment. Main outcome measures Presence bothersomeness tinnitus. Results 17.7% 5.8% reported or tinnitus, respectively. The was 8.7%. Multivariate logistic regression models suggested that age, difficulties, work noise exposure, ototoxic medication neuroticism were all positively both Reduced odds but not seen alcohol drinkers versus non-drinkers. Male gender increased while female At follow-up, those originally reporting 18.3% no Of still 9% improvement becoming more bothersome, rest unchanged. consumption being less difficulties bothersome. Conclusions This study is one few to provide on natural history non-clinical population, suggesting resolution relatively uncommon, worsening symptoms equally likely. There limited evidence for any modifiable lifestyle symptoms. In view largely persistent nature public health strategies should focus on: (1) primary prevention (2) managing have monitoring bothersomeness.