Comparison of oxygen mass transfer coefficient in simple and extractive fermentation systems

摘要: Abstract Aeration and agitation are important variables to ensure effective oxygen transfer rate during aerobic bioprocesses; therefore, the knowledge of volumetric mass coefficient ( k L a ) is required. In view selecting optimum requirements for extractive fermentation in aqueous two-phase system (ATPS), values typical ATPS medium were compared this work with those distilled water simple medium, absence biomass. selected as independent using 2 full factorial design. Both showed statistically significant effects on , highest parameter both media (241 s −1 (70.3 s observed at levels aeration (5 vvm) (1200 rpm). The then used establish mathematical correlations response function process variables. exponents power number N 3 D superficial gas velocity V s determined α  = 0.39 β  = 0.47, respectively) reasonable agreement ones reported literature several systems close  = 0.38  = 0.41). On other hand, expected by increased viscosity presence polyethylene glycol, their remarkably higher  = 0.50  = 1.0). A was found between experimental data three predicted theoretical models, under wide range operational conditions.