Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120.
作者： Akira Hirasawa , Keiko Tsumaya , Takeo Awaji , Susumu Katsuma , Tetsuya Adachi
DOI: 10.1038/NM1168
关键词:
摘要: Diabetes, a disease in which the body does not produce or use insulin properly, is serious global health problem. Gut polypeptides secreted response to food intake, such as glucagon-like peptide-1 (GLP-1), are potent incretin hormones that enhance glucose-dependent secretion of from pancreatic beta cells. Free fatty acids (FFAs) provide an important energy source and also act signaling molecules various cellular processes, including gut peptides. Here we show G-protein-coupled receptor, GPR120, abundantly expressed intestine, functions receptor for unsaturated long-chain FFAs. Furthermore, stimulation GPR120 by FFAs promotes GLP-1 vitro vivo, increases circulating insulin. Because most insulinotropic incretin, our results indicate GPR120-mediated induced dietary treatment diabetes.
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