Effect of phthalate esters on reproduction in rats.

摘要: Numerous plastic devices and materials used for medical, dental, food collection, processing, packaging are made of polyvinyl chloride) plasticized mainly with di-2-ethylhexyl phthalate (DEHP) to impart the desired physical chemical characteristics. Some finished products may contain more than 40% plasticizer, which be leached from material by blood (1) or milk (2) various other solutions. DEHP has generally not been considered a health hazard because its low acute oral toxicity (3-10) amount plastics is quite small. However, there evidence that readily hydrolyzed but accumulates in body tissues. When two patients were infused stored bags DEHP, Jaeger Rubin (11) found spleen, liver, lung, abdominal fat concentrations ranging 2.5 27 mg-% (dry weight). The teratogenic effects several esters when injected into yolk sac allantoic cavity applied chorioallantoic membrane developing chick embryos have reported Haberman others (12-14). More recently, tDepartment Dairy Science, Michigan State University, East Lansing, 48823. *To whom reprint requests should sent. *Supported Agricultural Experiment Station (journal article 6113). Singh et al. (15) teratogenicity rats without regard effect these compounds might on parturition. present study was undertaken determine dibutyl phthalate, dimethyl embryonic development