Cancer: A moving target.

摘要: An in silico, three-dimensional model of tumour evolution suggests that cell motility is a key factor the initial growth mass. The also reveals dynamics mutation spread. See Letter p.261 Although large can contain billions cells, these masses are highly homogeneous. A mass normal cells size would be expected to genetically diverse due slow collection modest random mutations following divisions, raising question how cancers maintain homogeneity at such scale. Here Martin Nowak and colleagues propose explains short-range migration turnover within provide an environment rapid mixing allow even small selective advantage dominate relevant time frame.