Genome dynamics and virulence in the human pathogen Candida glabrata

摘要: Although the yeast Candida glabrata is considered to be a part of commensal microflora in healthy individuals, during last years it has been frequently isolated from patients with mucosal and systemic fungal infections. Now as second most pathogenic after albicans. Despite its name, C. phylogenetically closer relative Saccharomyces cerevisiae than to C. Apparently, only recently changed life style become successful opportunistic pathogen. It found that this can rearrange genome cope surrounding environments, I show hereby clinical isolates enormous genomic plasticity. How reshuffles human pathogen remains elucidated. During decades, several studies have conducted find out mechanisms behind pathogenicity glabrata. Some shown adapt harsh conditions by changing number size chromosomes but intra- inter-chromosomal segmental duplications also observed. Moreover, great interest for researchers due its rapid development antifungal drug resistance. Therefore, involved rearrangement survive how tolerates azole therapy an interesting aspect study. In study developed new tool, RNAi, putative virulence genes.